Whitehead - MIT BioImgaing Center

Published Research

Recent papers from bioImaging researchers are highlighted. Animations and movies explain the basic concepts, methods, and results.

podosome
XY view of isosurface reconstruction showing that a podosome cluster (red) formed from a PCP (green).
bar = 3 microns

Macrophage podosomes assemble at the leading lamella by growth and fragmentation.

Evans JG, Correia I, Krasavina O, Watson N, Matsudaira P.

Using high resolution 3D and 4D light microscopy, Evans et al investigate the assembly and turnover of the dynamic adhesion structures in macrophages called podosomes. 3D kymography was used to quantify the effects of cytoskeleton-perturbing drugs on podosome dynamics and longevity.

Published online May 19, 2003 in The Journal of Cell Biology
Read: Abstract | Full Text

podosomeBioImaging Research Tour

Experience the four stages of our imaging strategy through a series of movies and diagrams showing how podosomes grow and fragment. Requires Flash plugin.

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