Bioimaging is much more than simply taking interesting pictures. In fact, image acquisition is but one stage (and not the first) in a logical, linear process. We define the art and science of biomolecular imaging as the four-stage strategy developed by the MIT Computational and Systems Biology Initiative (CSBi):

Manipulate

In this stage, the biological question is asked, prompting experiments in which molecules, cells, or tissues are modified in some defined manner (such as genetic mutation, application of a drug, or physical interactions with molecules or cells).

Measure

This is the imaging stage, which may involve a range of microscopy techniques.

Mine

The data is processed, quantified, and analyzed to produce quantitative results.

Model

The results are represented through computational, mechanical, chemical, and other models.

Each stage of the strategy presents challenges and opportunities, requires different tools and techniques, and builds on the previous stage. With the vast resources of the BioImaging Center, and the technical expertise of our staff, we are uniquely qualified to drive research through all stages, fulfilling project objectives and uncovering the previously unseen.

BioImaging
Research Tour

Experience the four stages of our imaging strategy through a series of movies and diagrams showing how podosomes grow and fragment. Requires Flash Plugin.